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A 2015 review in BioMed Research International, the most-cited summary of GHKs biology, describes the peptide stimulating both the synthesis and the breakdown of collagen and glycosaminoglycans, while nudging the metalloproteinases and their inhibitors in tandem
doi:10.1111/j.2047-2927.2013.00107.x
Skin sensitivity: an emerging signal Skin burning and abnormal touch sensitivity (dysesthesia) appears as a dose-related, reversible signal in two case series and post-market surveillance. Trials did not pre-specify it, and the tirzepatide label does not list it
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A patch test is recommended before using GHK-Cu products in any topical application study, as some users may experience skin sensitivity or irritation, and redness and dryness can occur with topical GHK-Cu use